Drug interactions
Docetaxel + Sarecycline
Severity: Minor
Docetaxel and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline is a tetracycline-class antibiotic that has been shown in vitro to inhibit P-glycoprotein, so a rise in docetaxel levels is theoretically possible. Clinical significance is uncertain and exposure to sarecycline is low.
What this interaction means in plain words
Docetaxel and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Docetaxel belongs to Oncology; Sarecycline belongs to Anti Bacterial.
Why it happens
Possible weak inhibition of P-glycoprotein efflux of docetaxel; not clinically established.
What to do
No routine change is needed; monitor for increased docetaxel adverse effects such as neutropenia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Docetaxel
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Docetaxel with Sarecycline?
MediHelp rates the interaction as minor. Docetaxel and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline is a tetracycline-class antibiotic that has been shown in vitro to inhibit P-glycoprotein, so a rise in docetaxel levels is theoretically possible. Clinical significance is uncertain and exposure to sarecycline is low.
How serious is the interaction between Docetaxel and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for increased docetaxel adverse effects such as neutropenia.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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