Drug interactions
Docetaxel + Voxelotor
Severity: Moderate
Docetaxel and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and raises exposure of sensitive CYP3A4 substrates. Docetaxel has a narrow therapeutic index and depends on CYP3A4 clearance, so toxicity such as myelosuppression may increase.
What this interaction means in plain words
Docetaxel and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Docetaxel belongs to Oncology; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4, decreasing docetaxel metabolism.
What to do
Monitor neutrophil counts and signs of docetaxel toxicity, and reduce the docetaxel dose if adverse effects occur. Consider alternatives to voxelotor where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Docetaxel
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Docetaxel with Voxelotor?
MediHelp rates the interaction as moderate. Docetaxel and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 and raises exposure of sensitive CYP3A4 substrates. Docetaxel has a narrow therapeutic index and depends on CYP3A4 clearance, so toxicity such as myelosuppression may increase.
How serious is the interaction between Docetaxel and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and signs of docetaxel toxicity, and reduce the docetaxel dose if adverse effects occur. Consider alternatives to voxelotor where feasible.
What other medicines interact with Docetaxel?
MediHelp also lists interactions of Docetaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Belatacept. The full list is on the Docetaxel page.
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