Drug interactions
Donepezil + Eliglustat
Severity: Moderate
Donepezil and Eliglustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat can prolong cardiac conduction intervals at high concentrations, and donepezil can prolong QT and cause bradycardia. Combining them may increase arrhythmia risk, particularly when eliglustat exposure is increased by CYP2D6 or CYP3A inhibitors. Donepezil is also a CYP2D6 and CYP3A4 substrate.
What this interaction means in plain words
Donepezil and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Eliglustat belongs to Miscellaneous.
Why it happens
Additive QT and conduction effects.
What to do
Obtain a baseline ECG and correct electrolyte disturbances. Avoid additional QT-prolonging drugs or CYP inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Donepezil with Eliglustat?
MediHelp rates the interaction as moderate. Donepezil and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat can prolong cardiac conduction intervals at high concentrations, and donepezil can prolong QT and cause bradycardia. Combining them may increase arrhythmia risk, particularly when eliglustat exposure is increased by CYP2D6 or CYP3A inhibitors. Donepezil is also a CYP2D6 and CYP3A4 substrate.
How serious is the interaction between Donepezil and Eliglustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolyte disturbances. Avoid additional QT-prolonging drugs or CYP inhibitors.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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