Drug interactions
Donepezil + Fluphenazine
Severity: Moderate
Donepezil and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and donepezil has been linked to torsades de pointes and bradycardia. Pharmacodynamically, donepezil may also worsen extrapyramidal symptoms while the antipsychotic opposes cholinergic effects.
What this interaction means in plain words
Donepezil and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, and opposing cholinergic and dopaminergic effects on motor function.
What to do
Check a baseline ECG and electrolytes and monitor for bradycardia, syncope and palpitations. Watch for worsening parkinsonism and reassess the need for both drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Fluphenazine?
MediHelp rates the interaction as moderate. Donepezil and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and donepezil has been linked to torsades de pointes and bradycardia. Pharmacodynamically, donepezil may also worsen extrapyramidal symptoms while the antipsychotic opposes cholinergic effects.
How serious is the interaction between Donepezil and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and monitor for bradycardia, syncope and palpitations. Watch for worsening parkinsonism and reassess the need for both drugs.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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