Drug interactions
Donepezil + Fosaprepitant
Severity: Minor
Donepezil and Fosaprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant, released from fosaprepitant, is a moderate CYP3A4 inhibitor after short-term dosing. A single-dose course is unlikely to raise donepezil levels meaningfully, so the clinical impact is small.
What this interaction means in plain words
Donepezil and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Donepezil belongs to Central Nervous System; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Weak to moderate, transient CYP3A4 inhibition by aprepitant reduces donepezil clearance.
What to do
No action is generally required; watch for increased nausea, bradycardia or dizziness in frail patients around the time of chemotherapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Donepezil with Fosaprepitant?
MediHelp rates the interaction as minor. Donepezil and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aprepitant, released from fosaprepitant, is a moderate CYP3A4 inhibitor after short-term dosing. A single-dose course is unlikely to raise donepezil levels meaningfully, so the clinical impact is small.
How serious is the interaction between Donepezil and Fosaprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally required; watch for increased nausea, bradycardia or dizziness in frail patients around the time of chemotherapy.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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