Drug interactions
Donepezil + Gemifloxacin
Severity: Moderate
Donepezil and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and donepezil can also cause bradycardia, raising torsades risk. Combined use may increase the likelihood of ventricular arrhythmia, particularly in older patients.
What this interaction means in plain words
Donepezil and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation, with donepezil's vagotonic bradycardia adding risk.
What to do
Consider a non-QT-prolonging antibiotic in patients with cardiac risk. Otherwise check ECG, heart rate and electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Gemifloxacin?
MediHelp rates the interaction as moderate. Donepezil and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and donepezil can also cause bradycardia, raising torsades risk. Combined use may increase the likelihood of ventricular arrhythmia, particularly in older patients.
How serious is the interaction between Donepezil and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-QT-prolonging antibiotic in patients with cardiac risk. Otherwise check ECG, heart rate and electrolytes.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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