Drug interactions
Donepezil + Indacaterol-glycopyrronium
Severity: Moderate
Donepezil and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil is a cholinesterase inhibitor that can cause bradycardia and QT prolongation, and indacaterol may modestly affect QT interval. Donepezil's cholinergic action also opposes the antimuscarinic action of glycopyrronium, though the clinical effect of inhaled glycopyrronium is likely small.
What this interaction means in plain words
Donepezil and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive QT effects, plus pharmacodynamic opposition between cholinesterase inhibition and muscarinic blockade.
What to do
Monitor heart rate and ECG in patients with cardiac risk factors or other QT-prolonging drugs. Watch for reduced bronchodilator response or increased cholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Donepezil and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil is a cholinesterase inhibitor that can cause bradycardia and QT prolongation, and indacaterol may modestly affect QT interval. Donepezil's cholinergic action also opposes the antimuscarinic action of glycopyrronium, though the clinical effect of inhaled glycopyrronium is likely small.
How serious is the interaction between Donepezil and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG in patients with cardiac risk factors or other QT-prolonging drugs. Watch for reduced bronchodilator response or increased cholinergic effects.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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