Drug interactions
Donepezil + Lenvatinib
Severity: Major
Donepezil and Lenvatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and the combination may increase the risk of ventricular arrhythmia including torsades de pointes. Lenvatinib can also cause electrolyte disturbances that add to the risk.
What this interaction means in plain words
Donepezil and Lenvatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Donepezil belongs to Central Nervous System; Lenvatinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check ECG and electrolytes at baseline and periodically, correcting potassium, magnesium and calcium. Consider an alternative to donepezil if QTc becomes prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Haloperidol + Lenvatinib Major
- Hydroxyzine + Lenvatinib Major
Frequently asked questions
Can I take Donepezil with Lenvatinib?
MediHelp rates the interaction as major. Donepezil and Lenvatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and the combination may increase the risk of ventricular arrhythmia including torsades de pointes. Lenvatinib can also cause electrolyte disturbances that add to the risk.
How serious is the interaction between Donepezil and Lenvatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline and periodically, correcting potassium, magnesium and calcium. Consider an alternative to donepezil if QTc becomes prolonged.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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