Drug interactions
Amisulpride + Lenvatinib
Severity: Major
Amisulpride and Lenvatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenvatinib has been associated with QT prolongation, and amisulpride has the same liability. Combination may increase the chance of ventricular arrhythmia.
What this interaction means in plain words
Amisulpride and Lenvatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Lenvatinib belongs to Oncology.
Why it happens
Additive prolongation of the QT interval.
What to do
Avoid where an alternative exists. Otherwise monitor ECG and keep potassium, magnesium and calcium normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
- Hydroxyzine + Lenvatinib Major
Frequently asked questions
Can I take Amisulpride with Lenvatinib?
MediHelp rates the interaction as major. Amisulpride and Lenvatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lenvatinib has been associated with QT prolongation, and amisulpride has the same liability. Combination may increase the chance of ventricular arrhythmia.
How serious is the interaction between Amisulpride and Lenvatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where an alternative exists. Otherwise monitor ECG and keep potassium, magnesium and calcium normal.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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