Drug interactions
Asenapine + Lenvatinib
Severity: Major
Asenapine and Lenvatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes, particularly with electrolyte disturbances or cardiac disease. Lenvatinib labeling advises ECG monitoring with other QT-prolonging drugs.
What this interaction means in plain words
Asenapine and Lenvatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Asenapine belongs to Central Nervous System; Lenvatinib belongs to Oncology.
Why it happens
Additive QTc prolongation through cardiac repolarization effects.
What to do
Obtain baseline and periodic ECGs and correct potassium, magnesium and calcium before and during therapy. Consider an alternative antipsychotic with lower QT liability if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
- Hydroxyzine + Lenvatinib Major
Frequently asked questions
Can I take Asenapine with Lenvatinib?
MediHelp rates the interaction as major. Asenapine and Lenvatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes, particularly with electrolyte disturbances or cardiac disease. Lenvatinib labeling advises ECG monitoring with other QT-prolonging drugs.
How serious is the interaction between Asenapine and Lenvatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and periodic ECGs and correct potassium, magnesium and calcium before and during therapy. Consider an alternative antipsychotic with lower QT liability if QTc becomes markedly prolonged.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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