Drug interactions
Chlorpromazine + Lenvatinib
Severity: Major
Chlorpromazine and Lenvatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so their combination may increase the risk of torsades de pointes. Lenvatinib labeling advises ECG monitoring with other QT-prolonging drugs.
What this interaction means in plain words
Chlorpromazine and Lenvatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpromazine belongs to Central Nervous System; Lenvatinib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Monitor ECG and correct potassium, magnesium and calcium disturbances. Consider an alternative to chlorpromazine if the QTc becomes significantly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
- Hydroxyzine + Lenvatinib Major
Frequently asked questions
Can I take Chlorpromazine with Lenvatinib?
MediHelp rates the interaction as major. Chlorpromazine and Lenvatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so their combination may increase the risk of torsades de pointes. Lenvatinib labeling advises ECG monitoring with other QT-prolonging drugs.
How serious is the interaction between Chlorpromazine and Lenvatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium, magnesium and calcium disturbances. Consider an alternative to chlorpromazine if the QTc becomes significantly prolonged.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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