Drug interactions
Donepezil + Letermovir
Severity: Moderate
Donepezil and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir is a moderate CYP3A4 inhibitor and may raise donepezil exposure. Higher levels can cause more cholinergic effects such as bradycardia, nausea and diarrhea.
What this interaction means in plain words
Donepezil and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Letermovir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated donepezil metabolism.
What to do
Monitor for bradycardia, gastrointestinal intolerance and syncope during letermovir therapy. Reduce the donepezil dose if cholinergic effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Donepezil with Letermovir?
MediHelp rates the interaction as moderate. Donepezil and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir is a moderate CYP3A4 inhibitor and may raise donepezil exposure. Higher levels can cause more cholinergic effects such as bradycardia, nausea and diarrhea.
How serious is the interaction between Donepezil and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bradycardia, gastrointestinal intolerance and syncope during letermovir therapy. Reduce the donepezil dose if cholinergic effects occur.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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