Drug interactions
Donepezil + Osimertinib
Severity: Moderate
Donepezil and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes. The risk is higher with bradycardia, electrolyte abnormalities or existing cardiac disease.
What this interaction means in plain words
Donepezil and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Osimertinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check ECG and electrolytes at baseline and periodically. Stop or change therapy if QTc becomes markedly prolonged or arrhythmia symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Osimertinib
Frequently asked questions
Can I take Donepezil with Osimertinib?
MediHelp rates the interaction as moderate. Donepezil and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes. The risk is higher with bradycardia, electrolyte abnormalities or existing cardiac disease.
How serious is the interaction between Donepezil and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline and periodically. Stop or change therapy if QTc becomes markedly prolonged or arrhythmia symptoms occur.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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