Drug interactions
Donepezil + Oxaliplatin
Severity: Moderate
Donepezil and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin has been associated with QT prolongation and torsades de pointes, and donepezil may add to this risk. The combination can increase the likelihood of ventricular arrhythmia, especially with electrolyte disturbances common in chemotherapy patients.
What this interaction means in plain words
Donepezil and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Oxaliplatin belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check baseline ECG and correct potassium, magnesium and calcium before oxaliplatin cycles. Monitor the ECG periodically, particularly if vomiting or diarrhea occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Donepezil with Oxaliplatin?
MediHelp rates the interaction as moderate. Donepezil and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaliplatin has been associated with QT prolongation and torsades de pointes, and donepezil may add to this risk. The combination can increase the likelihood of ventricular arrhythmia, especially with electrolyte disturbances common in chemotherapy patients.
How serious is the interaction between Donepezil and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct potassium, magnesium and calcium before oxaliplatin cycles. Monitor the ECG periodically, particularly if vomiting or diarrhea occurs.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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