Drug interactions
Donepezil + Perphenazine
Severity: Moderate
Donepezil and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes, particularly with other risk factors. Donepezil can also cause bradycardia, which further increases arrhythmia risk. Cholinesterase inhibition may additionally oppose the anticholinergic properties of perphenazine.
What this interaction means in plain words
Donepezil and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Additive QTc prolongation; donepezil also adds bradycardic effects.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Repeat the ECG after dose changes and avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Perphenazine?
MediHelp rates the interaction as moderate. Donepezil and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes, particularly with other risk factors. Donepezil can also cause bradycardia, which further increases arrhythmia risk. Cholinesterase inhibition may additionally oppose the anticholinergic properties of perphenazine.
How serious is the interaction between Donepezil and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Repeat the ECG after dose changes and avoid adding other QT-prolonging drugs.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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