Drug interactions
Donepezil + Solifenacin
Severity: Moderate
Donepezil and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil is associated with QT prolongation and torsades, and solifenacin also has a small QT effect. Their pharmacological actions are opposed, since cholinesterase inhibition counteracts antimuscarinic action, which may reduce the efficacy of both.
What this interaction means in plain words
Donepezil and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation, plus pharmacodynamic antagonism between a cholinesterase inhibitor and an antimuscarinic.
What to do
Avoid routine co-prescribing in dementia where possible. If both are needed, monitor the ECG and cognitive and urinary response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Solifenacin?
MediHelp rates the interaction as moderate. Donepezil and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil is associated with QT prolongation and torsades, and solifenacin also has a small QT effect. Their pharmacological actions are opposed, since cholinesterase inhibition counteracts antimuscarinic action, which may reduce the efficacy of both.
How serious is the interaction between Donepezil and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine co-prescribing in dementia where possible. If both are needed, monitor the ECG and cognitive and urinary response.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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