Drug interactions
Donepezil + Tipranavir
Severity: Minor
Donepezil and Tipranavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir is given with ritonavir, which inhibits CYP3A4 and CYP2D6, though tipranavir itself also induces CYP3A4, giving a mixed net effect on donepezil. Exposure could change unpredictably, and cholinergic effects may emerge.
What this interaction means in plain words
Donepezil and Tipranavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Donepezil belongs to Central Nervous System; Tipranavir belongs to Anti Virals.
Why it happens
Mixed CYP3A4 inhibition and induction from tipranavir/ritonavir, with CYP2D6 inhibition by ritonavir.
What to do
Monitor heart rate, GI tolerance and cognitive response; adjust donepezil dose to clinical effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Donepezil with Tipranavir?
MediHelp rates the interaction as minor. Donepezil and Tipranavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tipranavir is given with ritonavir, which inhibits CYP3A4 and CYP2D6, though tipranavir itself also induces CYP3A4, giving a mixed net effect on donepezil. Exposure could change unpredictably, and cholinergic effects may emerge.
How serious is the interaction between Donepezil and Tipranavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, GI tolerance and cognitive response; adjust donepezil dose to clinical effect.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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