Drug interactions
Donepezil + Vorinostat
Severity: Moderate
Donepezil and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil can prolong the QT interval, and vorinostat, a histone deacetylase inhibitor, has been associated with QT changes. Together they may add to arrhythmia risk, which matters in patients with cancer who often have electrolyte disturbances from vomiting or diarrhea.
What this interaction means in plain words
Donepezil and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Vorinostat belongs to Oncology.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Check an ECG at baseline and periodically, and correct potassium and magnesium before and during therapy. Consider an alternative to donepezil if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Donepezil with Vorinostat?
MediHelp rates the interaction as moderate. Donepezil and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil can prolong the QT interval, and vorinostat, a histone deacetylase inhibitor, has been associated with QT changes. Together they may add to arrhythmia risk, which matters in patients with cancer who often have electrolyte disturbances from vomiting or diarrhea.
How serious is the interaction between Donepezil and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG at baseline and periodically, and correct potassium and magnesium before and during therapy. Consider an alternative to donepezil if the QTc becomes markedly prolonged.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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