Drug interactions
Donepezil transdermal + Ribociclib
Severity: Moderate
Donepezil transdermal and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil is metabolized in part by CYP3A4 and CYP2D6. Ribociclib may raise donepezil levels, increasing cholinergic effects such as nausea, bradycardia and syncope. Donepezil can also prolong QT, adding to ribociclib's QT effect.
What this interaction means in plain words
Donepezil transdermal and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by ribociclib increases donepezil exposure, with additive QT effects.
What to do
Monitor heart rate, ECG and electrolytes, and watch for cholinergic adverse effects. Reduce donepezil dose if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Donepezil transdermal with Ribociclib?
MediHelp rates the interaction as moderate. Donepezil transdermal and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil is metabolized in part by CYP3A4 and CYP2D6. Ribociclib may raise donepezil levels, increasing cholinergic effects such as nausea, bradycardia and syncope. Donepezil can also prolong QT, adding to ribociclib's QT effect.
How serious is the interaction between Donepezil transdermal and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and electrolytes, and watch for cholinergic adverse effects. Reduce donepezil dose if these occur.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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