Drug interactions
Dopexamine + Hydrochlorothiazide-lisinopril
Severity: Moderate
Dopexamine and Hydrochlorothiazide-lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dopexamine, a beta-2 agonist used in acute care, can shift potassium into cells. With a thiazide diuretic that also depletes potassium, hypokalemia may become more pronounced and raise arrhythmia risk in critically ill patients.
What this interaction means in plain words
Dopexamine and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 stimulation drives intracellular potassium uptake, adding to renal potassium loss caused by thiazide.
What to do
Monitor serum potassium and ECG during dopexamine infusion, and replace potassium as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Dopexamine with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as moderate. Dopexamine and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dopexamine, a beta-2 agonist used in acute care, can shift potassium into cells. With a thiazide diuretic that also depletes potassium, hypokalemia may become more pronounced and raise arrhythmia risk in critically ill patients.
How serious is the interaction between Dopexamine and Hydrochlorothiazide-lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and ECG during dopexamine infusion, and replace potassium as required.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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