Drug interactions
Dopexamine + Perphenazine
Severity: Moderate
Dopexamine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dopexamine is a dopamine and beta2 receptor agonist used in acute settings, and perphenazine blocks dopamine receptors, which may reduce dopexamine's effects. Perphenazine's alpha-blockade may also add to vasodilation and hypotension.
What this interaction means in plain words
Dopexamine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at dopamine receptors plus additive alpha-adrenergic blockade.
What to do
Monitor hemodynamics closely and titrate dopexamine to response. Consider holding perphenazine during acute hemodynamic support if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Dopexamine with Perphenazine?
MediHelp rates the interaction as moderate. Dopexamine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dopexamine is a dopamine and beta2 receptor agonist used in acute settings, and perphenazine blocks dopamine receptors, which may reduce dopexamine's effects. Perphenazine's alpha-blockade may also add to vasodilation and hypotension.
How serious is the interaction between Dopexamine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemodynamics closely and titrate dopexamine to response. Consider holding perphenazine during acute hemodynamic support if feasible.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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