Drug interactions
Dopexamine + Promethazine
Severity: Minor
Dopexamine and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dopexamine is an intravenous catecholamine-like inotrope used in critical care, and promethazine can cause hypotension and sedation through alpha-blockade. No clear, clinically significant interaction is established, though promethazine may modestly oppose the pressor effect.
What this interaction means in plain words
Dopexamine and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible pharmacodynamic opposition through promethazine's alpha-adrenergic blockade; not well established.
What to do
Monitor blood pressure and heart rate if promethazine is given during dopexamine infusion.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dopexamine and Promethazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Frequently asked questions
Can I take Dopexamine with Promethazine?
MediHelp rates the interaction as minor. Dopexamine and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dopexamine is an intravenous catecholamine-like inotrope used in critical care, and promethazine can cause hypotension and sedation through alpha-blockade. No clear, clinically significant interaction is established, though promethazine may modestly oppose the pressor effect.
How serious is the interaction between Dopexamine and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate if promethazine is given during dopexamine infusion.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Cabergoline, Dopamine, Ibutilide. The full list is on the Promethazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
