Drug interactions
Dosulepin + Glycopyrronium
Severity: Moderate
Dosulepin and Glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a tricyclic antidepressant with notable anticholinergic activity. Combined with glycopyrronium it increases dry mouth, constipation, urinary retention, tachycardia and cognitive disturbance.
What this interaction means in plain words
Dosulepin and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Glycopyrronium belongs to Respiratory.
Why it happens
Additive pharmacodynamic antimuscarinic effects.
What to do
Monitor for anticholinergic effects, especially in older patients, and reduce doses or switch to a less anticholinergic antidepressant if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Glycopyrronium + Potassium chloride Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Glycopyrronium?
MediHelp rates the interaction as moderate. Dosulepin and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a tricyclic antidepressant with notable anticholinergic activity. Combined with glycopyrronium it increases dry mouth, constipation, urinary retention, tachycardia and cognitive disturbance.
How serious is the interaction between Dosulepin and Glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, especially in older patients, and reduce doses or switch to a less anticholinergic antidepressant if needed.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Potassium chloride, Abobotulinumtoxina. The full list is on the Glycopyrronium page.
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