Drug interactions
Dosulepin + Ipratropium-salbutamol
Severity: Moderate
Dosulepin and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a tricyclic antidepressant with marked anticholinergic effects, which could add to ipratropium, though systemic absorption of inhaled ipratropium is low. Tricyclics may also potentiate the cardiovascular effects of beta-agonists such as salbutamol, with a risk of tachycardia and arrhythmia.
What this interaction means in plain words
Dosulepin and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive antimuscarinic effects and tricyclic-related potentiation of adrenergic cardiovascular effects.
What to do
Monitor heart rate and rhythm and anticholinergic symptoms, particularly with high-dose or nebulized salbutamol. Use the lowest effective bronchodilator dose in patients with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Dosulepin and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a tricyclic antidepressant with marked anticholinergic effects, which could add to ipratropium, though systemic absorption of inhaled ipratropium is low. Tricyclics may also potentiate the cardiovascular effects of beta-agonists such as salbutamol, with a risk of tachycardia and arrhythmia.
How serious is the interaction between Dosulepin and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and rhythm and anticholinergic symptoms, particularly with high-dose or nebulized salbutamol. Use the lowest effective bronchodilator dose in patients with cardiac disease.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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