Drug interactions
Dosulepin + Isoproterenol
Severity: Moderate
Dosulepin and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as dosulepin can potentiate the cardiovascular effects of sympathomimetic amines. Isoproterenol may therefore provoke tachycardia and arrhythmias more readily.
What this interaction means in plain words
Dosulepin and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Isoproterenol belongs to Respiratory.
Why it happens
Dosulepin has anticholinergic and catecholamine-potentiating effects and proarrhythmic properties that add to beta-agonist chronotropic stimulation.
What to do
Monitor ECG and heart rate during isoproterenol infusion in patients on dosulepin, and titrate the dose cautiously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dosulepin and Isoproterenol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Isoproterenol
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Isoproterenol?
MediHelp rates the interaction as moderate. Dosulepin and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants such as dosulepin can potentiate the cardiovascular effects of sympathomimetic amines. Isoproterenol may therefore provoke tachycardia and arrhythmias more readily.
How serious is the interaction between Dosulepin and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate during isoproterenol infusion in patients on dosulepin, and titrate the dose cautiously.
What other medicines interact with Isoproterenol?
MediHelp also lists interactions of Isoproterenol with, for example, Adrenaline-articaine, Bisoprolol, Budesonide-formoterol. The full list is on the Isoproterenol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
