Drug interactions
Dosulepin + Metaxalone
Severity: Moderate
Dosulepin and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a sedating tricyclic antidepressant and combining it with metaxalone may intensify drowsiness and psychomotor impairment. Anticholinergic effects of the tricyclic may also compound confusion in vulnerable patients.
What this interaction means in plain words
Dosulepin and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression; both agents have sedative properties.
What to do
Monitor for excessive sedation and dizziness, especially after starting or raising either dose. Lower the dose of one agent if impairment develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Metaxalone?
MediHelp rates the interaction as moderate. Dosulepin and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a sedating tricyclic antidepressant and combining it with metaxalone may intensify drowsiness and psychomotor impairment. Anticholinergic effects of the tricyclic may also compound confusion in vulnerable patients.
How serious is the interaction between Dosulepin and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and dizziness, especially after starting or raising either dose. Lower the dose of one agent if impairment develops.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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