Drug interactions
Dosulepin + Orphenadrin
Severity: Moderate
Dosulepin and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a sedating tricyclic antidepressant with anticholinergic activity, and orphenadrine adds further antimuscarinic and CNS effects. The combination can cause excess drowsiness, confusion, constipation, urinary retention and tachycardia.
What this interaction means in plain words
Dosulepin and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive antimuscarinic and CNS depressant effects.
What to do
Use the lowest effective doses and avoid in elderly patients or those with glaucoma or prostatic hypertrophy. Monitor for sedation, anticholinergic symptoms and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Orphenadrin?
MediHelp rates the interaction as moderate. Dosulepin and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a sedating tricyclic antidepressant with anticholinergic activity, and orphenadrine adds further antimuscarinic and CNS effects. The combination can cause excess drowsiness, confusion, constipation, urinary retention and tachycardia.
How serious is the interaction between Dosulepin and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and avoid in elderly patients or those with glaucoma or prostatic hypertrophy. Monitor for sedation, anticholinergic symptoms and heart rate.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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