Drug interactions
Dosulepin + Quetiapine
Severity: Moderate
Dosulepin and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a sedating tricyclic antidepressant and quetiapine is also sedating, so the combination can cause excessive drowsiness and orthostatic hypotension. Both drugs can also prolong the QT interval, and additive anticholinergic effects are possible.
What this interaction means in plain words
Dosulepin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Additive CNS depression, alpha-1 blockade and QT-prolonging effects.
What to do
Start with low doses and monitor sedation, blood pressure and orthostasis. Obtain an ECG and check electrolytes if there are cardiac risk factors or doses are high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Quetiapine?
MediHelp rates the interaction as moderate. Dosulepin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a sedating tricyclic antidepressant and quetiapine is also sedating, so the combination can cause excessive drowsiness and orthostatic hypotension. Both drugs can also prolong the QT interval, and additive anticholinergic effects are possible.
How serious is the interaction between Dosulepin and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor sedation, blood pressure and orthostasis. Obtain an ECG and check electrolytes if there are cardiac risk factors or doses are high.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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