Drug interactions
Dosulepin + Sumatriptan
Severity: Moderate
Dosulepin and Sumatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sumatriptan is a serotonin agonist and dosulepin, a tricyclic antidepressant, inhibits serotonin reuptake. Serotonin syndrome is rare but possible and presents with agitation, tremor, sweating, hyperthermia and clonus.
What this interaction means in plain words
Dosulepin and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Sumatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects through 5-HT1B/1D agonism and serotonin reuptake inhibition.
What to do
Counsel the patient on the symptoms of serotonin syndrome and monitor after starting or increasing doses. Stop both drugs and treat if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Sumatriptan?
MediHelp rates the interaction as moderate. Dosulepin and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sumatriptan is a serotonin agonist and dosulepin, a tricyclic antidepressant, inhibits serotonin reuptake. Serotonin syndrome is rare but possible and presents with agitation, tremor, sweating, hyperthermia and clonus.
How serious is the interaction between Dosulepin and Sumatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on the symptoms of serotonin syndrome and monitor after starting or increasing doses. Stop both drugs and treat if symptoms develop.
What other medicines interact with Sumatriptan?
MediHelp also lists interactions of Sumatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Sumatriptan page.
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