Drug interactions
Doxapram + Tranylcypromine
Severity: Major
Doxapram and Tranylcypromine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxapram has pressor effects, and in patients on MAO inhibitors the combination may cause an exaggerated rise in blood pressure, with a risk of hypertensive crisis. Doxapram labeling cautions against use with MAOIs.
What this interaction means in plain words
Doxapram and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Doxapram belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic pressor effects of doxapram and MAO-inhibitor-enhanced catecholamine activity.
What to do
Avoid doxapram in patients on tranylcypromine where possible. If it must be used, give it at the lowest dose with continuous blood pressure and heart rhythm monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Doxapram
- Desflurane + Doxapram Major
- Dextroamphetamine + Doxapram Major
- Doxapram + Isocarboxazid Major
- Doxapram + Ketamine Major
- Doxapram + Linezolid Major
- Doxapram + Lisdexamfetamine Major
Frequently asked questions
Can I take Doxapram with Tranylcypromine?
MediHelp rates the interaction as major. Doxapram and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Doxapram has pressor effects, and in patients on MAO inhibitors the combination may cause an exaggerated rise in blood pressure, with a risk of hypertensive crisis. Doxapram labeling cautions against use with MAOIs.
How serious is the interaction between Doxapram and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid doxapram in patients on tranylcypromine where possible. If it must be used, give it at the lowest dose with continuous blood pressure and heart rhythm monitoring.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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