Drug interactions
Doxazosin + Iloperidone
Severity: Moderate
Doxazosin and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone has alpha-1 adrenergic antagonist activity and commonly causes orthostatic hypotension and dizziness. Combined with doxazosin, these effects are additive and can lead to syncope or falls, especially during iloperidone titration.
What this interaction means in plain words
Doxazosin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Iloperidone belongs to Central Nervous System.
Why it happens
Additive alpha-1 adrenergic blockade.
What to do
Titrate iloperidone slowly and check orthostatic blood pressure. Reduce doxazosin dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Doxazosin with Iloperidone?
MediHelp rates the interaction as moderate. Doxazosin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone has alpha-1 adrenergic antagonist activity and commonly causes orthostatic hypotension and dizziness. Combined with doxazosin, these effects are additive and can lead to syncope or falls, especially during iloperidone titration.
How serious is the interaction between Doxazosin and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate iloperidone slowly and check orthostatic blood pressure. Reduce doxazosin dose if symptomatic hypotension occurs.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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