Drug interactions
Doxazosin + Imidapril
Severity: Moderate
Doxazosin and Imidapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an alpha-blocker with an ACE inhibitor may cause an exaggerated first-dose hypotensive response, with dizziness or syncope in susceptible patients.
What this interaction means in plain words
Doxazosin and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Imidapril belongs to Cardiovascular.
Why it happens
Additive vasodilation from alpha-1 blockade and ACE inhibition.
What to do
Start at low doses, preferably at bedtime, and monitor blood pressure and orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Doxazosin and Imidapril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Doxazosin with Imidapril?
MediHelp rates the interaction as moderate. Doxazosin and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an alpha-blocker with an ACE inhibitor may cause an exaggerated first-dose hypotensive response, with dizziness or syncope in susceptible patients.
How serious is the interaction between Doxazosin and Imidapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start at low doses, preferably at bedtime, and monitor blood pressure and orthostatic symptoms.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
