Drug interactions
Eplerenone + Imidapril
Severity: Major
Eplerenone and Imidapril: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors and eplerenone both reduce potassium excretion, so hyperkalemia may develop, particularly with renal impairment or diabetes.
What this interaction means in plain words
Eplerenone and Imidapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eplerenone belongs to Cardiovascular; Imidapril belongs to Cardiovascular.
Why it happens
Additive suppression of the renin-angiotensin-aldosterone system.
What to do
Monitor potassium and renal function at baseline, early, and regularly. Avoid potassium supplements and reduce doses if hyperkalemia occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
- Acetylsalicylic acid + Imidapril Moderate
Frequently asked questions
Can I take Eplerenone with Imidapril?
MediHelp rates the interaction as major. Eplerenone and Imidapril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. ACE inhibitors and eplerenone both reduce potassium excretion, so hyperkalemia may develop, particularly with renal impairment or diabetes.
How serious is the interaction between Eplerenone and Imidapril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and renal function at baseline, early, and regularly. Avoid potassium supplements and reduce doses if hyperkalemia occurs.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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