Drug interactions
Imidapril + Spironolactone
Severity: Major
Imidapril and Spironolactone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Together these drugs can cause serious hyperkalemia and additive hypotension, especially in renal impairment or diabetes. Severe hyperkalemia may cause dangerous arrhythmias.
What this interaction means in plain words
Imidapril and Spironolactone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Imidapril belongs to Cardiovascular; Spironolactone belongs to Cardiovascular.
Why it happens
ACE inhibition lowers aldosterone while spironolactone blocks the receptor, additively reducing renal potassium excretion.
What to do
Check potassium and creatinine at baseline, within about a week, and regularly afterward. Avoid potassium supplements and reduce or stop spironolactone if potassium rises.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Triamterene Major
- Acetylsalicylic acid + Imidapril Moderate
Frequently asked questions
Can I take Imidapril with Spironolactone?
MediHelp rates the interaction as major. Imidapril and Spironolactone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Together these drugs can cause serious hyperkalemia and additive hypotension, especially in renal impairment or diabetes. Severe hyperkalemia may cause dangerous arrhythmias.
How serious is the interaction between Imidapril and Spironolactone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and creatinine at baseline, within about a week, and regularly afterward. Avoid potassium supplements and reduce or stop spironolactone if potassium rises.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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