Drug interactions
Imidapril + Pregabalin
Severity: Major
Imidapril and Pregabalin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors such as imidapril and pregabalin have each been linked to angioedema, so the combination may increase the likelihood of facial, oral or laryngeal swelling. Airway compromise can be life-threatening.
What this interaction means in plain words
Imidapril and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Imidapril belongs to Cardiovascular; Pregabalin belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic risk of angioedema; ACE inhibitors raise bradykinin levels while pregabalin has an independent association with angioedema.
What to do
Avoid the combination in patients with a history of angioedema and consider an alternative to the ACE inhibitor, such as an ARB, if appropriate. Advise patients to seek emergency care for any swelling of the lips, tongue or throat.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pregabalin
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
- Acetylsalicylic acid + Imidapril Moderate
Frequently asked questions
Can I take Imidapril with Pregabalin?
MediHelp rates the interaction as major. Imidapril and Pregabalin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. ACE inhibitors such as imidapril and pregabalin have each been linked to angioedema, so the combination may increase the likelihood of facial, oral or laryngeal swelling. Airway compromise can be life-threatening.
How serious is the interaction between Imidapril and Pregabalin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with a history of angioedema and consider an alternative to the ACE inhibitor, such as an ARB, if appropriate. Advise patients to seek emergency care for any swelling of the lips, tongue or throat.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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