Drug interactions
Doxazosin + Labetalol
Severity: Moderate
Doxazosin and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol has alpha-1 and beta blocking activity, so adding doxazosin increases the risk of excessive hypotension and orthostatic symptoms. Falls and syncope are possible, particularly in older patients.
What this interaction means in plain words
Doxazosin and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Labetalol belongs to Cardiovascular.
Why it happens
Additive alpha-1 adrenergic blockade, with added beta blockade from labetalol.
What to do
Use low starting doses and titrate slowly, monitoring orthostatic blood pressure. Reduce one of the doses if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Doxazosin and Labetalol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Doxazosin with Labetalol?
MediHelp rates the interaction as moderate. Doxazosin and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Labetalol has alpha-1 and beta blocking activity, so adding doxazosin increases the risk of excessive hypotension and orthostatic symptoms. Falls and syncope are possible, particularly in older patients.
How serious is the interaction between Doxazosin and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use low starting doses and titrate slowly, monitoring orthostatic blood pressure. Reduce one of the doses if symptomatic hypotension develops.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
