Drug interactions
Doxazosin + Mefenamic acid
Severity: Moderate
Doxazosin and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefenamic acid may attenuate the blood pressure lowering effect of doxazosin. Clinical significance depends on duration and dose of NSAID use.
What this interaction means in plain words
Doxazosin and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Mefenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis leads to sodium and fluid retention and reduced vasodilation.
What to do
Monitor blood pressure if mefenamic acid is used more than briefly. Adjust antihypertensive dosing if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Doxazosin with Mefenamic acid?
MediHelp rates the interaction as moderate. Doxazosin and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefenamic acid may attenuate the blood pressure lowering effect of doxazosin. Clinical significance depends on duration and dose of NSAID use.
How serious is the interaction between Doxazosin and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if mefenamic acid is used more than briefly. Adjust antihypertensive dosing if control worsens.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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