Drug interactions
Doxazosin + Metoprolol
Severity: Moderate
Doxazosin and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use gives additive blood pressure reduction, and postural hypotension may be more evident at treatment initiation or after dose increases. The combination is often used deliberately but needs careful titration.
What this interaction means in plain words
Doxazosin and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Metoprolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects of alpha-1 blockade and beta-1 blockade.
What to do
Start doxazosin at a low dose at bedtime and increase gradually. Monitor orthostatic blood pressure and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Doxazosin with Metoprolol?
MediHelp rates the interaction as moderate. Doxazosin and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use gives additive blood pressure reduction, and postural hypotension may be more evident at treatment initiation or after dose increases. The combination is often used deliberately but needs careful titration.
How serious is the interaction between Doxazosin and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start doxazosin at a low dose at bedtime and increase gradually. Monitor orthostatic blood pressure and heart rate.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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