Drug interactions
Doxazosin + Nisoldipine
Severity: Moderate
Doxazosin and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure by distinct mechanisms, so combining them can cause additive hypotension, dizziness and reflex tachycardia, particularly at initiation.
What this interaction means in plain words
Doxazosin and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Nisoldipine belongs to Cardiovascular.
Why it happens
Additive vasodilation from alpha-1 blockade and L-type calcium channel blockade.
What to do
Monitor blood pressure and orthostatic symptoms when starting or titrating. Reduce the dose of one agent if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Doxazosin with Nisoldipine?
MediHelp rates the interaction as moderate. Doxazosin and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure by distinct mechanisms, so combining them can cause additive hypotension, dizziness and reflex tachycardia, particularly at initiation.
How serious is the interaction between Doxazosin and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or titrating. Reduce the dose of one agent if hypotension occurs.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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