Drug interactions
Doxazosin + Piroxicam
Severity: Moderate
Doxazosin and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piroxicam may reduce the blood pressure lowering effect of doxazosin. Sustained NSAID use can lead to loss of blood pressure control.
What this interaction means in plain words
Doxazosin and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Piroxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis causes sodium and water retention and reduces vasodilation.
What to do
Monitor blood pressure when piroxicam is started or stopped. Use the lowest effective NSAID dose and adjust antihypertensive therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Doxazosin with Piroxicam?
MediHelp rates the interaction as moderate. Doxazosin and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piroxicam may reduce the blood pressure lowering effect of doxazosin. Sustained NSAID use can lead to loss of blood pressure control.
How serious is the interaction between Doxazosin and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when piroxicam is started or stopped. Use the lowest effective NSAID dose and adjust antihypertensive therapy if needed.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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