Drug interactions
Doxepin + Eribulin
Severity: Moderate
Doxepin and Eribulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both can prolong the QT interval, and tricyclic antidepressants carry arrhythmia risk. Their combination may increase the chance of torsades de pointes.
What this interaction means in plain words
Doxepin and Eribulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Eribulin belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Check baseline ECG and electrolytes and repeat ECG during therapy. Consider a non-QT-prolonging alternative in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eribulin
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Eribulin?
MediHelp rates the interaction as moderate. Doxepin and Eribulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both can prolong the QT interval, and tricyclic antidepressants carry arrhythmia risk. Their combination may increase the chance of torsades de pointes.
How serious is the interaction between Doxepin and Eribulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes and repeat ECG during therapy. Consider a non-QT-prolonging alternative in high-risk patients.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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