Drug interactions
Doxepin + Fingolimod
Severity: Moderate
Doxepin and Fingolimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin, a tricyclic antidepressant, can prolong QTc and conduction, and fingolimod slows heart rate. Combined use may increase risk of arrhythmia, particularly at higher doxepin doses.
What this interaction means in plain words
Doxepin and Fingolimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Fingolimod belongs to Central Nervous System.
Why it happens
Additive QT and conduction effects with fingolimod-induced bradycardia.
What to do
Obtain a baseline ECG and monitor during fingolimod initiation. Keep doxepin at the lowest effective dose and correct electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Fingolimod?
MediHelp rates the interaction as moderate. Doxepin and Fingolimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin, a tricyclic antidepressant, can prolong QTc and conduction, and fingolimod slows heart rate. Combined use may increase risk of arrhythmia, particularly at higher doxepin doses.
How serious is the interaction between Doxepin and Fingolimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor during fingolimod initiation. Keep doxepin at the lowest effective dose and correct electrolytes.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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