Drug interactions
Doxepin + Fluticasone-salmeterol
Severity: Moderate
Doxepin and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as doxepin may potentiate the cardiovascular effects of beta-agonists like salmeterol. This can result in tachycardia, arrhythmia and QT prolongation, mainly at antidepressant doses.
What this interaction means in plain words
Doxepin and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Additive QT and adrenergic effects, with tricyclic inhibition of noradrenaline reuptake enhancing beta-agonist response.
What to do
Monitor heart rate and ECG, particularly with higher doxepin doses or cardiac disease. Low-dose doxepin for insomnia carries less risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Doxepin and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants such as doxepin may potentiate the cardiovascular effects of beta-agonists like salmeterol. This can result in tachycardia, arrhythmia and QT prolongation, mainly at antidepressant doses.
How serious is the interaction between Doxepin and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG, particularly with higher doxepin doses or cardiac disease. Low-dose doxepin for insomnia carries less risk.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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