Drug interactions
Doxepin + Frovatriptan
Severity: Moderate
Doxepin and Frovatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin inhibits serotonin reuptake and triptans stimulate serotonin receptors, so the combination carries a theoretical risk of serotonin syndrome. Reported cases with triptans and antidepressants are uncommon.
What this interaction means in plain words
Doxepin and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Frovatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic activity from reuptake inhibition by doxepin plus 5-HT1B/1D agonism by frovatriptan.
What to do
Counsel the patient on symptoms of serotonin syndrome and monitor, especially after dose changes. Stop the combination and treat if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Frovatriptan?
MediHelp rates the interaction as moderate. Doxepin and Frovatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin inhibits serotonin reuptake and triptans stimulate serotonin receptors, so the combination carries a theoretical risk of serotonin syndrome. Reported cases with triptans and antidepressants are uncommon.
How serious is the interaction between Doxepin and Frovatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on symptoms of serotonin syndrome and monitor, especially after dose changes. Stop the combination and treat if symptoms develop.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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