Drug interactions
Doxepin + Galantamine
Severity: Moderate
Doxepin and Galantamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin has notable anticholinergic activity that can oppose the effect of galantamine and worsen cognition and confusion. Sedation may also be additive.
What this interaction means in plain words
Doxepin and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Galantamine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism of cholinesterase inhibition by antimuscarinic activity; doxepin is also a CYP2D6 substrate.
What to do
Prefer antidepressants with low anticholinergic activity in patients on galantamine. If doxepin is needed, use the lowest dose and monitor cognition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Galantamine?
MediHelp rates the interaction as moderate. Doxepin and Galantamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin has notable anticholinergic activity that can oppose the effect of galantamine and worsen cognition and confusion. Sedation may also be additive.
How serious is the interaction between Doxepin and Galantamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer antidepressants with low anticholinergic activity in patients on galantamine. If doxepin is needed, use the lowest dose and monitor cognition.
What other medicines interact with Galantamine?
MediHelp also lists interactions of Galantamine with, for example, Memantine-donepezil, Physostigmine, Ponesimod. The full list is on the Galantamine page.
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