Drug interactions
Doxepin + Gliclazide
Severity: Minor
Doxepin and Gliclazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as doxepin have been reported to enhance glucose lowering and may alter glycaemic control in patients taking sulfonylureas. Hypoglycaemia symptoms may also be confused with other effects of the antidepressant.
What this interaction means in plain words
Doxepin and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxepin belongs to Dermatology; Gliclazide belongs to Endocrine.
Why it happens
The mechanism is not well established; tricyclics may influence insulin sensitivity and glucose regulation.
What to do
Monitor blood glucose when starting or stopping doxepin and reduce the gliclazide dose if hypoglycaemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Gliclazide?
MediHelp rates the interaction as minor. Doxepin and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants such as doxepin have been reported to enhance glucose lowering and may alter glycaemic control in patients taking sulfonylureas. Hypoglycaemia symptoms may also be confused with other effects of the antidepressant.
How serious is the interaction between Doxepin and Gliclazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping doxepin and reduce the gliclazide dose if hypoglycaemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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