Drug interactions
Doxepin + Lofexidine
Severity: Moderate
Doxepin and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a sedating tricyclic antidepressant that can add to lofexidine-related drowsiness and hypotension, and both agents can prolong the QT interval. Tricyclics may also blunt the antihypertensive effect of centrally acting alpha-2 agonists.
What this interaction means in plain words
Doxepin and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Lofexidine belongs to Central Nervous System.
Why it happens
Additive sedation and QT prolongation, plus possible antagonism of alpha-2 agonist effects by tricyclic antidepressants.
What to do
Obtain a baseline ECG and monitor QTc, heart rate, blood pressure and sedation. Correct electrolyte disturbances and use the lowest effective doxepin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Lofexidine?
MediHelp rates the interaction as moderate. Doxepin and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a sedating tricyclic antidepressant that can add to lofexidine-related drowsiness and hypotension, and both agents can prolong the QT interval. Tricyclics may also blunt the antihypertensive effect of centrally acting alpha-2 agonists.
How serious is the interaction between Doxepin and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc, heart rate, blood pressure and sedation. Correct electrolyte disturbances and use the lowest effective doxepin dose.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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