Drug interactions
Doxepin + Metformin-pioglitazone
Severity: Minor
Doxepin and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants like doxepin can alter glucose regulation and have occasionally been linked to hypoglycemia in diabetic patients. Effects are inconsistent and usually small.
What this interaction means in plain words
Doxepin and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxepin belongs to Dermatology; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Possible pharmacodynamic effect on glucose and insulin regulation; mechanism not firmly established.
What to do
Monitor blood glucose when starting or changing doxepin and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Doxepin and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants like doxepin can alter glucose regulation and have occasionally been linked to hypoglycemia in diabetic patients. Effects are inconsistent and usually small.
How serious is the interaction between Doxepin and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or changing doxepin and adjust antidiabetic therapy if needed.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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