Drug interactions
Doxepin + Metformin-repaglinide
Severity: Minor
Doxepin and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as doxepin have been reported to alter glycemic control and may enhance the hypoglycemic effect of antidiabetic drugs. The effect is variable and usually modest.
What this interaction means in plain words
Doxepin and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxepin belongs to Dermatology; Metformin-repaglinide belongs to Endocrine.
Why it happens
Proposed effects on insulin sensitivity and glucose handling; the mechanism is not well established.
What to do
Monitor blood glucose when doxepin is started or stopped. Adjust the antidiabetic dose if hypoglycemia or hyperglycemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Metformin-repaglinide?
MediHelp rates the interaction as minor. Doxepin and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants such as doxepin have been reported to alter glycemic control and may enhance the hypoglycemic effect of antidiabetic drugs. The effect is variable and usually modest.
How serious is the interaction between Doxepin and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when doxepin is started or stopped. Adjust the antidiabetic dose if hypoglycemia or hyperglycemia develops.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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