Drug interactions
Doxepin + Pioglitazone
Severity: Minor
Doxepin and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as doxepin have been reported to alter glycemic control in some patients, and may cause weight gain that can offset the effect of antidiabetic therapy. Clinically significant effects with pioglitazone are uncommon and unpredictable.
What this interaction means in plain words
Doxepin and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxepin belongs to Dermatology; Pioglitazone belongs to Endocrine.
Why it happens
Possible additive effects on glucose regulation and appetite or weight; the mechanism is not firmly established.
What to do
Monitor blood glucose when doxepin is started or stopped in a patient on pioglitazone. Adjust the antidiabetic dose only if glycemic control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pioglitazone
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Pioglitazone?
MediHelp rates the interaction as minor. Doxepin and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants such as doxepin have been reported to alter glycemic control in some patients, and may cause weight gain that can offset the effect of antidiabetic therapy. Clinically significant effects with pioglitazone are uncommon and unpredictable.
How serious is the interaction between Doxepin and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when doxepin is started or stopped in a patient on pioglitazone. Adjust the antidiabetic dose only if glycemic control changes.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
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